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KMID : 0357920030370060393
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Korean Journal of Pathology
2003 Volume.37 No. 6 p.393 ~ p.399
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Expression of p21, p53 and bd-2 Proteins in Invasive Ductal Carcinoma of the Breast
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Jo Hyang-Jeong
Yun Ki-Jung
Moon Hyung-Bae
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Abstract
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Background: This study was designed to investigate the prognostic significance of p21, p53, and bcl-2 proteins in invasive ductal carcinoma of the breast.
Methods: Seventy-two cases of invasive ductal carcinoma were examined by immunohistochemical staining for p21, p53 and bcl-2 proteins. The results were correlated with clinicopathological variables, including age, tumor size, histologic grade, nuclear grade, lymph node status, estrogen receptor (ER) and progesterone receptor (PR) expression.
Results: Of 72 cases, p21, p53 and bcl-2 proteins were positive in 25(34.8%), 35(50.0%) and 27(37.5%), respectively. There were no statisticaly significant correlations between the p21 protein expression and the other clinicopathological variables. The expression of p53 protein, however, showed a significant relation to ER expression, and that of bcl-2 was positively correlated with tumor size. In survival analysis, p21, p53 and bcl-2 proteins, nuclear grade and lymph node stafus were associated with survival rate.
Conclusions: These results indicate that p21, p53, and bcl-2 proteins might play a role in tumorigenesis of breast carcinoma. In addition, the increased expression of p21, p53, and bcl-2 proteins could be used as factors suggesting poor prognosis in breast carcinomas.
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KEYWORD
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p21, p53, bcl-2, Breast Neoplasms
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